Find it here: http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00498-7
Time-Restricted Feeding Is a Preventative and Therapeutic Intervention against Diverse Nutritional ChallengesAmandine Chaix
- Time-restricted feeding (TRF) confines food access to 912 hr during the active phase
- TRF is a therapeutic intervention against obesity without calorie restriction
- TRF protects against metabolic diseases even when briefly interrupted on weekends
- TRF is effective against high-fat, high-fructose, and high-sucrose diets
SummaryBecause current therapeutics for obesity are limited and only offer modest improvements, novel interventions are needed. Preventing obesity with time-restricted feeding (TRF; 89 hr food access in the active phase) is promising, yet its therapeutic applicability against preexisting obesity, diverse dietary conditions, and less stringent eating patterns is unknown. Here we tested TRF in mice under diverse nutritional challenges. We show that TRF attenuated metabolic diseases arising from a variety of obesogenic diets, and that benefits were proportional to the fasting duration. Furthermore, protective effects were maintained even when TRF was temporarily interrupted by ad libitum access to food during weekends, a regimen particularly relevant to human lifestyle. Finally, TRF stabilized and reversed the progression of metabolic diseases in mice with preexisting obesity and type II diabetes. We establish clinically relevant parameters of TRF for preventing and treating obesity and metabolic disorders, including type II diabetes, hepatic steatosis, and hypercholesterolemia.
Received: July 23, 2014; Received in revised form: September 15, 2014; Accepted: October 31, 2014;
© 2014 Elsevier Inc. Published by Elsevier Inc. All rights reserved.